Fig. 3.

CASC2 is a sponge of miR-222. a Potential binding sites of miR-222 in CASC2 were predicted by bioinformatics analysis. b Enrichment of CASC2 and miR-222 was analyzed in PASMCs after Ago2 RIP. c Luciferase activity was measured in PASMCs co-transfected with CASC2-WT or CASC2-MUT and miR-NC, miR-222 or anti-miR-NC, anti-miR-222. d MiR-222 expression in PASMCs was examined after transfection with CASC2 or si-CASC2 using qRT-PCR, and results were presented as the average of three independent replicates. ***P < 0.001