Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Mar 17;11:123. doi: 10.1186/s13287-020-01634-6

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 7 — Anti-tumor activity of intratumoral injection of peptide-loaded DC-activated CIK cell preparations (P-DC-CIK) or non-peptide-loaded NP-DC-CIK cell preparations on two prostate cancer xenograft models derived from prostatospheroids. a DU145 xenografts. Upon intratumoral injection of P-DC-CIK, DU145 xenograft tumors grew very slowly. b 22Rv1 xenografts. Castration-refractory 22Rv1-CRPC xenografts were induced in SCID mice bearing 22Rv1 xenografts by castration when the tumor sizes reached about 5 mm³. Similar to DU145 xenografts, intratumoral injection of P-DC-CIK could significantly suppress the tumor growth as compared to injection of NP-DC-CIK control. Histochemical TUNEL staining revealed that significant increases of TMR red-labeled apoptotic cells were detected in both DU145 and 22Rv1 xenografts treated with P-DC-CIK as compared to NP-DC-CIK. *P < 0.05; ***P < 0.001 versus NP-DC-CIK control