Table 3.
Over-represented biological processes of the BM-MSC secretome under TNFα compared with control C1
| Biological process | TNFα (P value) | Control C1 (P value) | ID (term GO) |
|---|---|---|---|
| Positive regulation of GTPase activity | 1.76 × 10−20 | 2.65 × 10−01 | GO:0043547 |
| Cellular response to tumor necrosis factor | 2.75 × 10−22 | 3.52 × 10−01 | GO:0071356 |
| Granulocyte chemotaxis | 1.49 × 10−27 | 1.04 × 10−09 | GO:0071621 |
| Positive regulation of ERK1 and ERK2 cascade | 3.34 × 10−19 | 4.51 × 10− 01 | GO:0070374 |
| Cytokine-mediated signaling pathway | 6.74 × 10−29 | 1.32 × 10−07 | GO:0019221 |
| Inflammatory response | 1.88 × 10−24 | 1.28 × 10−03 | GO:0006954 |
| Antimicrobial humoral immune response mediated by antimicrobial peptide | 6.43 × 10−03 | – | GO:0061844 |
| Cellular response to lipopolysaccharide | 1.18 × 10−02 | 3.24 × 10−04 | GO:0071222 |
| MAPK cascade | 3.42 × 10−10 | 3.45 × 10−02 | GO:0000165 |
| Innate immune response | 7.55 × 10−09 | – | GO:0045087 |
Analysis of data using the PANTHER classification system obtained with a cytokine array in the culture media. The corresponding P value is shown according to the binomial test. The identity (ID) of the gene products (GO terms from PANTHER GO slim) describing the function is indicated