7. Investigations of heterogeneity between subgroups of tests using first rank symptoms to diagnose schizophrenia versus other psychoses.
| Schizophrenia versus other psychoses | Number of studies | Number of patients | Summary sensitivity % (95% CI) |
Summary specificity % (95% CI) |
Likelihood Ratio Test[1] (P value) | |
| First rank symptoms used as part of reference standard: | Yes | 4 | 1326 | 60.9 (46.5, 736.) | 82.3 (65.0, 92.1) | 0.1 |
| Unclear | 12 | 2744 | 56.8 (48.1, 65.0) | 72.0 (60.6, 81.1) | ||
| All admissions to a psychiatric ward or with specific psychoses: | All hospitalised | 5 | 481 | 62.1 (47.8, 74.5) | 79.3 (62.0, 90.0) | 0.3 |
| Psychosis only | 11 | 3589 | 56.7 (47.7, 65.2) | 73.2 (61.1, 82.1) | ||
| If definition included schizoaffective and/or schizophreniform: | Not reported | 5 | 1312 | 39.6 (32.1, 47.6) | 85.3 (73.5, 92.4) | 0.004 |
| Schizophrenic only | 7 | 1328 | 63.3 (56.3, 69.9) | 63.6 (48.1, 76.7) | ||
| Number of first rank symptoms needed for a diagnosis of schizophrenia: | At least one | 8 | 2608 | 58.7 (48.0, 68.6) | 69.3 (56.9, 79.5) | 0.5 |
| Not reported | 7 | 721 | 59.8 (47.8, 70.8) | 76.6 (63.0, 86.3) | ||
1Likelihood ratio test for model with and without covariate