Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Mar 17;18:29. doi: 10.1186/s12915-020-00765-9

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 2 — Increase in gut-homing CD4⁺ T cell numbers induced by anti-CTLA-4 therapy is independent of CD103. a Knocking out CD103 decreased β7 expression in blood CD4⁺ and CD8⁺ T cells. Flow cytometric analysis of activated gut-homing T cells in the blood from WT and CD103 KO mice. Representative flow plots depicting activated gut-homing T cells (β7⁺CD44⁺) (left) and quantification of activated gut-homing T cells (right). The upper profiles were gated on live CD4⁺ T cells, and the lower profiles were gated on live CD8⁺ T cells. b The increase in gut-homing CD4⁺ T cell numbers by anti-CTLA-4 therapy was independent of CD103. Flow cytometric analysis of activated gut-homing CD4⁺ T cells in the blood 10 days after isotype antibody (Ctrl) (upper profiles) or anti-CTLA-4 mAb (lower profiles) treatment from WT and CD103 KO mice. The left profiles are representative flow plots depicting activated gut-homing T cells (β7⁺CD44⁺), and the right bar graph shows the fold change in activated gut-homing T cells (β7⁺CD44⁺) between the anti-CTLA-4 group and the IgG group. There were 5 mice in each group, data represent mean ± SEM, ***P < 0.001