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. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: Nat Immunol. 2019 Jun;20(6):670–671. doi: 10.1038/s41590-019-0373-6

Figure 1. Proliferation of peritoneal macrophages is dependent on Bhlhe40.

Figure 1.

In quiescent large peritoneal macrophages (LPMs), the transcription factors Maf and Mafb inhibit the expression of KLF4 and c-Myc, limiting self-renewal. Cytokines, such as IL-4, induce the entry of LPMs into the cell cycle. The progression of LPMs through the cell cycle is dependent on the transcription factor Bhlhe40 and its ability to bind the promoter elements of Maf and Mafb locus and represses their transcription, thus leading to the increased expression of the pro-proliferative transcription factors KLF4 and c-Myc.