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Comparison of Model Estimates Between TDF and TAF
| Parameter (TDF vs TAF) | TDF | TAF | TAF Fraction (%) |
|---|---|---|---|
| TFV CL/F from BP (L/hr) | 40.4 | 4.60* | 11.3% |
| TFVdp elimination from PBMCs (hr−1) | 0.0309 | 0.0124 | 40.1% |
| (K40 vs K30) | |||
| Transit of TFV from BP to SP (hr−1) | 0.0152 | 0.00947 | 62.3% |
| (K25 vs K46) | |||
| Elimination of TFV from the SP (hr−1) | 0.0126 | 1.98 | 15,700% |
| (K50 vs K60) | |||
=based on a fixed TFV volume of distribution of 2000 L
