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. Author manuscript; available in PMC: 2020 Mar 18.
Published in final edited form as: ChemistrySelect. 2019 Dec 5;4(45):13363–13369. doi: 10.1002/slct.201903696

Figure 1.

Figure 1.

A) Maintenance of meiosis arrest in the prophase I oocyte is facilitated by elevated cAMP. Active PKA phosphorylates WEE2 which in turn translocates into the germinal vesicle (GV) to phosphorylate CDK1, a form that prevents complexing with cyclin B and formation of active MPF. B) A decline in cAMP inactivates PKA and the phosphorylating activity on WEE2 so that it is unable to enter the GV. Without an inhibitory phosphate in place, CDK1 complexes with cyclin B to form MPF and drive meiosis resumption.