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. Author manuscript; available in PMC: 2021 Jan 1.
Published in final edited form as: Adv Ther (Weinh). 2019 Dec 17;3(1):1900094. doi: 10.1002/adtp.201900094

Figure 2.

Figure 2.

Association state of lispro with different formulation excipients. Zinc-free insulin lispro association states when formulated in i) phosphate buffer, sodium chloride (0.9%) (LS), ii) phosphate buffer with glycerol (2.6%) (LG), iii) phosphate buffer with glycerol (2.6%) and meta-cresol (0.315%) (LGM), and iv) phosphate buffer with glycerol (2.6%) and phenoxyethanol (0.85%) (LGPhE). Formulations were compared against a formulation of commercial Humalog. a) SEC-MALS elution profiles. b) Number-averaged molecular weight of the distribution of insulin lispro association states. c–g) Ratio of monomers, dimers, and hexamers in each formulation.