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. Author manuscript; available in PMC: 2020 Sep 5.
Published in final edited form as: Adv Funct Mater. 2019 Jul 8;29(36):1903753. doi: 10.1002/adfm.201903753

Figure 1. In vitro CEST MRI of Gel/HA/PEGDA composite hydrogel and its individual components.

Figure 1.

a) Scheme of hydrogel formation. PEGDA serves as a crosslinker between Gel and HA. b) Dependence of composite hydrogel MTRasym values on saturation powers of B1=1.2, 2.4, 3.6, 5.9, and 7.2 μT. Two peaks (0.5–2.0 and 3.6 ppm) are present. c) Z-spectra and d) MTRasym values of the three individual hydrogel components, Gel-SH, HA-SH, and PEGDA, for a saturation power of 3.6 μT. Inset show a CEST MR image of the three individual components at 3.6 ppm. e) Chemical structure of Gel-SH showing the multiple amide protons that are exchangeable with water.