Table 2.
Results of the simulation study with n = 400
| Event | Naive estimator (β̂) | Robust estimator with Cox PH Censoring (β̂CRC) |
Robust estimator with Sur- vival Trees (β̂CR) |
Avg | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Scenario | Rate | Truth | Bias | ESE | MSE | SE/ESE | CP | Bias | ESE | MSE | SE/ESE | CP | Bias | ESE | MSE | SE/ESE | CP | Groups |
| n = 400 | ||||||||||||||||||
| Null | ||||||||||||||||||
| C: 1 | 0.819 | 0.000 | 0.005 | 0.120 | 1.449 | 1.042 | 0.965 | −0.003 | 0.132 | 1.754 | 0.945 | 0.928 | 0.005 | 0.120 | 1.449 | 1.042 | 0.965 | 1.000 |
| C: 2 | 0.549 | 0.000 | 0.006 | 0.152 | 2.327 | 1.015 | 0.962 | 0.001 | 0.199 | 3.959 | 0.922 | 0.934 | 0.004 | 0.185 | 3.418 | 0.954 | 0.949 | 5.001 |
| C: 3 | 0.606 | 0.000 | 0.005 | 0.140 | 1.957 | 1.037 | 0.959 | −0.014 | 0.363 | 13.166 | 0.586 | 0.915 | 0.002 | 0.164 | 2.681 | 0.984 | 0.938 | 4.319 |
| C: 4 | 0.678 | 0.000 | 0.007 | 0.133 | 1.759 | 1.021 | 0.956 | −0.024 | 1.237 | 152.934 | 0.334 | 0.824 | 0.005 | 0.145 | 2.110 | 1.011 | 0.951 | 3.566 |
| C: 5 | 0.416 | 0.000 | 0.005 | 0.181 | 3.259 | 1.007 | 0.944 | −0.006 | 0.190 | 3.611 | 0.995 | 0.948 | 0.002 | 0.221 | 4.859 | 0.982 | 0.943 | 6.449 |
| C: 6 | 0.374 | 0.000 | 0.016 | 0.205 | 4.206 | 1.014 | 0.952 | 0.002 | 0.226 | 5.104 | 0.935 | 0.937 | 0.026 | 0.277 | 7.734 | 0.907 | 0.930 | 8.321 |
| C: 7 | 0.380 | 0.000 | 0.002 | 0.185 | 3.435 | 1.017 | 0.952 | −0.008 | 0.308 | 9.491 | 0.838 | 0.903 | 0.002 | 0.262 | 6.858 | 0.931 | 0.934 | 6.760 |
| PH | ||||||||||||||||||
| C: 1 | 0.766 | −0.404 | −0.004 | 0.135 | 1.828 | 0.977 | 0.944 | −0.002 | 0.132 | 1.739 | 0.998 | 0.952 | −0.004 | 0.135 | 1.828 | 0.977 | 0.944 | 1.000 |
| C: 2 | 0.493 | −0.404 | −0.003 | 0.168 | 2.827 | 0.985 | 0.948 | 0.004 | 0.231 | 5.324 | 0.877 | 0.939 | −0.005 | 0.206 | 4.221 | 0.939 | 0.943 | 5.484 |
| C: 3 | 0.550 | −0.404 | −0.004 | 0.158 | 2.482 | 0.983 | 0.949 | −0.002 | 0.300 | 9.002 | 0.738 | 0.921 | −0.007 | 0.186 | 3.444 | 0.943 | 0.937 | 4.984 |
| C: 4 | 0.619 | −0.404 | −0.002 | 0.150 | 2.244 | 0.960 | 0.944 | −0.047 | 1.166 | 136.049 | 0.335 | 0.839 | −0.004 | 0.168 | 2.823 | 0.933 | 0.931 | 4.464 |
| C: 5 | 0.371 | −0.404 | −0.012 | 0.193 | 3.740 | 1.008 | 0.947 | −0.001 | 0.212 | 4.500 | 0.968 | 0.936 | −0.014 | 0.262 | 6.855 | 0.903 | 0.923 | 6.810 |
| C: 6 | 0.341 | −0.404 | −0.007 | 0.233 | 5.421 | 0.961 | 0.934 | −0.002 | 0.232 | 5.395 | 0.987 | 0.944 | −0.007 | 0.320 | 10.223 | 0.874 | 0.918 | 8.811 |
| C: 7 | 0.333 | −0.404 | 0.000 | 0.204 | 4.145 | 0.994 | 0.952 | −0.004 | 0.339 | 11.491 | 0.848 | 0.919 | −0.002 | 0.299 | 8.947 | 0.890 | 0.916 | 7.223 |
| Non-PH | ||||||||||||||||||
| C: 1 | 0.885 | −0.647 | −0.003 | 0.124 | 1.536 | 1.002 | 0.944 | 0.009 | 0.122 | 1.504 | 1.013 | 0.955 | −0.003 | 0.124 | 1.536 | 1.002 | 0.944 | 1.000 |
| C: 2 | 0.664 | −0.647 | 0.133 | 0.144 | 3.850 | 0.994 | 0.842 | 0.001 | 0.177 | 3.118 | 0.886 | 0.908 | 0.011 | 0.158 | 2.506 | 0.977 | 0.944 | 3.617 |
| C: 3 | 0.721 | −0.647 | 0.095 | 0.138 | 2.821 | 0.992 | 0.898 | −0.032 | 0.204 | 4.253 | 0.795 | 0.924 | 0.003 | 0.146 | 2.144 | 0.985 | 0.939 | 3.029 |
| C: 4 | 0.784 | −0.647 | 0.045 | 0.131 | 1.905 | 1.002 | 0.937 | −0.110 | 1.089 | 119.679 | 0.210 | 0.908 | −0.009 | 0.136 | 1.866 | 0.988 | 0.941 | 2.377 |
| C: 5 | 0.508 | −0.647 | 0.202 | 0.163 | 6.719 | 1.001 | 0.763 | 0.106 | 0.173 | 4.121 | 0.971 | 0.898 | 0.023 | 0.190 | 3.641 | 0.971 | 0.942 | 5.642 |
| C: 6 | 0.485 | −0.647 | 0.202 | 0.194 | 7.855 | 0.995 | 0.810 | 0.163 | 0.196 | 6.496 | 1.001 | 0.863 | 0.027 | 0.247 | 6.164 | 0.923 | 0.924 | 6.836 |
| C: 7 | 0.500 | −0.647 | 0.263 | 0.165 | 9.638 | 0.983 | 0.615 | −0.004 | 0.270 | 7.283 | 0.793 | 0.901 | 0.029 | 0.202 | 4.161 | 0.966 | 0.941 | 5.571 |
Each scenario is repeated 1000 times. Event rate refers to the average proportion of the sample with an observed event. Truth refers to the Monte Carlo average of β̂ at n = 2000 and under censoring scenario 1. ESE refers to the empirical standard error as calculated through the replicated datasets. MSE refers to the mean squared error times 1000. SE/ESE refers to the average ratio of analytically calculated sandwich standard error to the ESE. CP refers to the coverage probability of the 95 % confidence intervals. Avg Groups refer to the average number of censoring-specific groups derived from the chosen tree used to obtain β̂CR