Skip to main content
. Author manuscript; available in PMC: 2020 Mar 18.
Published in final edited form as: Stat Biosci. 2016 Aug 18;9(2):406–430. doi: 10.1007/s12561-016-9162-z

Table 2.

Results of the simulation study with n = 400

Event Naive estimator (β̂) Robust estimator with Cox PH
Censoring (β̂CRC)
Robust estimator with Sur-
vival Trees (β̂CR)
Avg




Scenario Rate Truth Bias ESE MSE SE/ESE CP Bias ESE MSE SE/ESE CP Bias ESE MSE SE/ESE CP Groups
n = 400
  Null
    C: 1 0.819 0.000 0.005 0.120 1.449 1.042 0.965 −0.003 0.132 1.754 0.945 0.928 0.005 0.120 1.449 1.042 0.965 1.000
    C: 2 0.549 0.000 0.006 0.152 2.327 1.015 0.962 0.001 0.199 3.959 0.922 0.934 0.004 0.185 3.418 0.954 0.949 5.001
    C: 3 0.606 0.000 0.005 0.140 1.957 1.037 0.959 −0.014 0.363 13.166 0.586 0.915 0.002 0.164 2.681 0.984 0.938 4.319
    C: 4 0.678 0.000 0.007 0.133 1.759 1.021 0.956 −0.024 1.237 152.934 0.334 0.824 0.005 0.145 2.110 1.011 0.951 3.566
    C: 5 0.416 0.000 0.005 0.181 3.259 1.007 0.944 −0.006 0.190 3.611 0.995 0.948 0.002 0.221 4.859 0.982 0.943 6.449
    C: 6 0.374 0.000 0.016 0.205 4.206 1.014 0.952 0.002 0.226 5.104 0.935 0.937 0.026 0.277 7.734 0.907 0.930 8.321
    C: 7 0.380 0.000 0.002 0.185 3.435 1.017 0.952 −0.008 0.308 9.491 0.838 0.903 0.002 0.262 6.858 0.931 0.934 6.760
  PH
    C: 1 0.766 −0.404 −0.004 0.135 1.828 0.977 0.944 −0.002 0.132 1.739 0.998 0.952 −0.004 0.135 1.828 0.977 0.944 1.000
    C: 2 0.493 −0.404 −0.003 0.168 2.827 0.985 0.948 0.004 0.231 5.324 0.877 0.939 −0.005 0.206 4.221 0.939 0.943 5.484
    C: 3 0.550 −0.404 −0.004 0.158 2.482 0.983 0.949 −0.002 0.300 9.002 0.738 0.921 −0.007 0.186 3.444 0.943 0.937 4.984
    C: 4 0.619 −0.404 −0.002 0.150 2.244 0.960 0.944 −0.047 1.166 136.049 0.335 0.839 −0.004 0.168 2.823 0.933 0.931 4.464
    C: 5 0.371 −0.404 −0.012 0.193 3.740 1.008 0.947 −0.001 0.212 4.500 0.968 0.936 −0.014 0.262 6.855 0.903 0.923 6.810
    C: 6 0.341 −0.404 −0.007 0.233 5.421 0.961 0.934 −0.002 0.232 5.395 0.987 0.944 −0.007 0.320 10.223 0.874 0.918 8.811
    C: 7 0.333 −0.404 0.000 0.204 4.145 0.994 0.952 −0.004 0.339 11.491 0.848 0.919 −0.002 0.299 8.947 0.890 0.916 7.223
  Non-PH
    C: 1 0.885 −0.647 −0.003 0.124 1.536 1.002 0.944 0.009 0.122 1.504 1.013 0.955 −0.003 0.124 1.536 1.002 0.944 1.000
    C: 2 0.664 −0.647 0.133 0.144 3.850 0.994 0.842 0.001 0.177 3.118 0.886 0.908 0.011 0.158 2.506 0.977 0.944 3.617
    C: 3 0.721 −0.647 0.095 0.138 2.821 0.992 0.898 −0.032 0.204 4.253 0.795 0.924 0.003 0.146 2.144 0.985 0.939 3.029
    C: 4 0.784 −0.647 0.045 0.131 1.905 1.002 0.937 −0.110 1.089 119.679 0.210 0.908 −0.009 0.136 1.866 0.988 0.941 2.377
    C: 5 0.508 −0.647 0.202 0.163 6.719 1.001 0.763 0.106 0.173 4.121 0.971 0.898 0.023 0.190 3.641 0.971 0.942 5.642
    C: 6 0.485 −0.647 0.202 0.194 7.855 0.995 0.810 0.163 0.196 6.496 1.001 0.863 0.027 0.247 6.164 0.923 0.924 6.836
    C: 7 0.500 −0.647 0.263 0.165 9.638 0.983 0.615 −0.004 0.270 7.283 0.793 0.901 0.029 0.202 4.161 0.966 0.941 5.571

Each scenario is repeated 1000 times. Event rate refers to the average proportion of the sample with an observed event. Truth refers to the Monte Carlo average of β̂ at n = 2000 and under censoring scenario 1. ESE refers to the empirical standard error as calculated through the replicated datasets. MSE refers to the mean squared error times 1000. SE/ESE refers to the average ratio of analytically calculated sandwich standard error to the ESE. CP refers to the coverage probability of the 95 % confidence intervals. Avg Groups refer to the average number of censoring-specific groups derived from the chosen tree used to obtain β̂CR