Table 3.
Results of the simulation study with n = 800
| Event | Naive estimator (β̂) | Robust estimator with Cox PH Censoring (β̂CRC) |
Robust estimator with Sur- vival Trees (β̂CR) |
Avg | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Scenario | Rate | Truth | Bias | ESE | MSE | SE/ESE | CP | Bias | ESE | MSE | SE/ESE | CP | Bias | ESE | MSE | SE/ESE | CP | Groups |
| n = 800 | ||||||||||||||||||
| Null | ||||||||||||||||||
| C: 1 | 0.819 | 0.000 | −0.003 | 0.090 | 0.812 | 0.983 | 0.937 | 0.000 | 0.092 | 0.851 | 0.958 | 0.941 | −0.003 | 0.090 | 0.812 | 0.983 | 0.937 | 1.000 |
| C: 2 | 0.547 | 0.000 | −0.001 | 0.109 | 1.189 | 1.001 | 0.952 | 0.002 | 0.152 | 2.310 | 0.885 | 0.933 | −0.006 | 0.136 | 1.856 | 0.948 | 0.940 | 9.378 |
| C: 3 | 0.606 | 0.000 | −0.002 | 0.101 | 1.026 | 1.010 | 0.943 | −0.009 | 0.193 | 3.712 | 0.820 | 0.931 | −0.002 | 0.118 | 1.393 | 0.997 | 0.949 | 7.888 |
| C: 4 | 0.677 | 0.000 | −0.003 | 0.096 | 0.913 | 1.001 | 0.948 | −0.060 | 1.353 | 183.228 | 0.307 | 0.842 | −0.008 | 0.107 | 1.154 | 0.981 | 0.944 | 7.599 |
| C: 5 | 0.415 | 0.000 | −0.001 | 0.132 | 1.733 | 0.973 | 0.945 | −0.001 | 0.138 | 1.908 | 0.973 | 0.948 | −0.003 | 0.171 | 2.919 | 0.930 | 0.923 | 13.725 |
| C: 6 | 0.374 | 0.000 | −0.002 | 0.148 | 2.185 | 0.990 | 0.951 | 0.003 | 0.149 | 2.226 | 1.006 | 0.946 | 0.002 | 0.197 | 3.875 | 0.953 | 0.941 | 17.677 |
| C: 7 | 0.380 | 0.000 | 0.002 | 0.131 | 1.719 | 1.011 | 0.956 | 0.007 | 0.215 | 4.607 | 0.914 | 0.944 | 0.006 | 0.193 | 3.740 | 0.941 | 0.944 | 12.784 |
| PH | ||||||||||||||||||
| C: 1 | 0.767 | −0.404 | 0.001 | 0.093 | 0.873 | 0.996 | 0.947 | 0.006 | 0.096 | 0.924 | 0.968 | 0.935 | 0.001 | 0.093 | 0.873 | 0.996 | 0.947 | 1.000 |
| C: 2 | 0.494 | −0.404 | −0.004 | 0.120 | 1.451 | 0.968 | 0.942 | 0.004 | 0.162 | 2.613 | 0.901 | 0.933 | −0.007 | 0.152 | 2.322 | 0.922 | 0.932 | 10.281 |
| C: 3 | 0.548 | −0.404 | 0.001 | 0.113 | 1.265 | 0.970 | 0.933 | 0.003 | 0.218 | 4.748 | 0.761 | 0.931 | 0.001 | 0.137 | 1.881 | 0.935 | 0.944 | 9.250 |
| C: 4 | 0.618 | −0.404 | 0.001 | 0.103 | 1.064 | 0.984 | 0.944 | −0.051 | 1.055 | 111.532 | 0.371 | 0.859 | 0.001 | 0.124 | 1.531 | 0.930 | 0.939 | 8.751 |
| C: 5 | 0.370 | −0.404 | −0.003 | 0.138 | 1.895 | 0.995 | 0.956 | 0.008 | 0.149 | 2.212 | 0.981 | 0.945 | −0.008 | 0.180 | 3.241 | 0.967 | 0.945 | 14.329 |
| C: 6 | 0.342 | −0.404 | −0.004 | 0.156 | 2.435 | 1.008 | 0.954 | 0.002 | 0.167 | 2.770 | 0.975 | 0.938 | −0.009 | 0.208 | 4.327 | 0.993 | 0.943 | 18.525 |
| C: 7 | 0.332 | −0.404 | 0.005 | 0.144 | 2.081 | 0.989 | 0.942 | −0.001 | 0.248 | 6.128 | 0.879 | 0.931 | −0.001 | 0.216 | 4.670 | 0.927 | 0.930 | 14.440 |
| Non-PH | ||||||||||||||||||
| C: 1 | 0.885 | −0.647 | −0.002 | 0.086 | 0.740 | 1.017 | 0.952 | −0.004 | 0.085 | 0.731 | 1.025 | 0.952 | −0.002 | 0.086 | 0.740 | 1.017 | 0.952 | 1.000 |
| C: 2 | 0.664 | −0.647 | 0.132 | 0.100 | 2.725 | 1.013 | 0.739 | −0.003 | 0.122 | 1.495 | 0.925 | 0.932 | 0.003 | 0.112 | 1.260 | 0.985 | 0.941 | 6.989 |
| C: 3 | 0.723 | −0.647 | 0.095 | 0.094 | 1.799 | 1.023 | 0.839 | −0.034 | 0.136 | 1.969 | 0.858 | 0.936 | 0.001 | 0.102 | 1.043 | 1.011 | 0.956 | 5.962 |
| C: 4 | 0.784 | −0.647 | 0.047 | 0.090 | 1.036 | 1.021 | 0.912 | −0.035 | 0.344 | 11.954 | 0.472 | 0.906 | −0.010 | 0.096 | 0.933 | 1.002 | 0.951 | 5.071 |
| C: 5 | 0.508 | −0.647 | 0.204 | 0.115 | 5.487 | 1.003 | 0.568 | 0.095 | 0.127 | 2.509 | 0.942 | 0.858 | 0.022 | 0.135 | 1.870 | 0.988 | 0.945 | 11.260 |
| C: 6 | 0.486 | −0.647 | 0.208 | 0.139 | 6.244 | 0.977 | 0.650 | 0.153 | 0.136 | 4.188 | 1.016 | 0.802 | 0.041 | 0.178 | 3.322 | 0.930 | 0.925 | 14.517 |
| C: 7 | 0.500 | −0.647 | 0.261 | 0.111 | 8.049 | 1.024 | 0.363 | −0.032 | 0.190 | 3.725 | 0.836 | 0.895 | 0.025 | 0.143 | 2.113 | 1.000 | 0.946 | 9.887 |
Each scenario is repeated 1000 times. Event rate refers to the average proportion of the sample with an observed event. Truth refers to the Monte Carlo average of β̂ at n = 2000 and under censoring scenario 1. ESE refers to the empirical standard error as calculated through the replicated datasets. MSE refers to the mean squared error times 1000. SE/ESE refers to the average ratio of analytically calculated sandwich standard error to the ESE. CP refers to the coverage probability of the 95 % confidence intervals. Avg Groups refer to the average number of censoring-specific groups derived from the chosen tree used to obtain β̂CR