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. Author manuscript; available in PMC: 2020 Mar 18.
Published in final edited form as: Stat Biosci. 2016 Aug 18;9(2):406–430. doi: 10.1007/s12561-016-9162-z

Table 3.

Results of the simulation study with n = 800

Event Naive estimator (β̂) Robust estimator with Cox PH
Censoring (β̂CRC)
Robust estimator with Sur-
vival Trees (β̂CR)
Avg




Scenario Rate Truth Bias ESE MSE SE/ESE CP Bias ESE MSE SE/ESE CP Bias ESE MSE SE/ESE CP Groups
n = 800
  Null
    C: 1 0.819 0.000 −0.003 0.090 0.812 0.983 0.937 0.000 0.092 0.851 0.958 0.941 −0.003 0.090 0.812 0.983 0.937 1.000
    C: 2 0.547 0.000 −0.001 0.109 1.189 1.001 0.952 0.002 0.152 2.310 0.885 0.933 −0.006 0.136 1.856 0.948 0.940 9.378
    C: 3 0.606 0.000 −0.002 0.101 1.026 1.010 0.943 −0.009 0.193 3.712 0.820 0.931 −0.002 0.118 1.393 0.997 0.949 7.888
    C: 4 0.677 0.000 −0.003 0.096 0.913 1.001 0.948 −0.060 1.353 183.228 0.307 0.842 −0.008 0.107 1.154 0.981 0.944 7.599
    C: 5 0.415 0.000 −0.001 0.132 1.733 0.973 0.945 −0.001 0.138 1.908 0.973 0.948 −0.003 0.171 2.919 0.930 0.923 13.725
    C: 6 0.374 0.000 −0.002 0.148 2.185 0.990 0.951 0.003 0.149 2.226 1.006 0.946 0.002 0.197 3.875 0.953 0.941 17.677
    C: 7 0.380 0.000 0.002 0.131 1.719 1.011 0.956 0.007 0.215 4.607 0.914 0.944 0.006 0.193 3.740 0.941 0.944 12.784
  PH
    C: 1 0.767 −0.404 0.001 0.093 0.873 0.996 0.947 0.006 0.096 0.924 0.968 0.935 0.001 0.093 0.873 0.996 0.947 1.000
    C: 2 0.494 −0.404 −0.004 0.120 1.451 0.968 0.942 0.004 0.162 2.613 0.901 0.933 −0.007 0.152 2.322 0.922 0.932 10.281
    C: 3 0.548 −0.404 0.001 0.113 1.265 0.970 0.933 0.003 0.218 4.748 0.761 0.931 0.001 0.137 1.881 0.935 0.944 9.250
    C: 4 0.618 −0.404 0.001 0.103 1.064 0.984 0.944 −0.051 1.055 111.532 0.371 0.859 0.001 0.124 1.531 0.930 0.939 8.751
    C: 5 0.370 −0.404 −0.003 0.138 1.895 0.995 0.956 0.008 0.149 2.212 0.981 0.945 −0.008 0.180 3.241 0.967 0.945 14.329
    C: 6 0.342 −0.404 −0.004 0.156 2.435 1.008 0.954 0.002 0.167 2.770 0.975 0.938 −0.009 0.208 4.327 0.993 0.943 18.525
    C: 7 0.332 −0.404 0.005 0.144 2.081 0.989 0.942 −0.001 0.248 6.128 0.879 0.931 −0.001 0.216 4.670 0.927 0.930 14.440
  Non-PH
    C: 1 0.885 −0.647 −0.002 0.086 0.740 1.017 0.952 −0.004 0.085 0.731 1.025 0.952 −0.002 0.086 0.740 1.017 0.952 1.000
    C: 2 0.664 −0.647 0.132 0.100 2.725 1.013 0.739 −0.003 0.122 1.495 0.925 0.932 0.003 0.112 1.260 0.985 0.941 6.989
    C: 3 0.723 −0.647 0.095 0.094 1.799 1.023 0.839 −0.034 0.136 1.969 0.858 0.936 0.001 0.102 1.043 1.011 0.956 5.962
    C: 4 0.784 −0.647 0.047 0.090 1.036 1.021 0.912 −0.035 0.344 11.954 0.472 0.906 −0.010 0.096 0.933 1.002 0.951 5.071
    C: 5 0.508 −0.647 0.204 0.115 5.487 1.003 0.568 0.095 0.127 2.509 0.942 0.858 0.022 0.135 1.870 0.988 0.945 11.260
    C: 6 0.486 −0.647 0.208 0.139 6.244 0.977 0.650 0.153 0.136 4.188 1.016 0.802 0.041 0.178 3.322 0.930 0.925 14.517
    C: 7 0.500 −0.647 0.261 0.111 8.049 1.024 0.363 −0.032 0.190 3.725 0.836 0.895 0.025 0.143 2.113 1.000 0.946 9.887

Each scenario is repeated 1000 times. Event rate refers to the average proportion of the sample with an observed event. Truth refers to the Monte Carlo average of β̂ at n = 2000 and under censoring scenario 1. ESE refers to the empirical standard error as calculated through the replicated datasets. MSE refers to the mean squared error times 1000. SE/ESE refers to the average ratio of analytically calculated sandwich standard error to the ESE. CP refers to the coverage probability of the 95 % confidence intervals. Avg Groups refer to the average number of censoring-specific groups derived from the chosen tree used to obtain β̂CR