Fig. 3.

Mas-deficient mice (Mas) reveal normal levels of cell proliferation in the adult dentate gyrus (DG). a The number of proliferating cells in running animals and sedentary controls (baseline) was quantified on day 7, 24 h after the first of three i.p. BrdU injections. b No difference in the number of BrdU-positive cells was observed at baseline or following running in Mas compared with WT. One-way ANOVA, F(3,19) = 31.65, p < 0.0001, followed by Tukey’s post hoc test, ***p < 0.001 relatively to sedentary control of the same genotype; data are presented as mean ± SEM. c No difference was observed in running distances between genotypes. d, e Representative confocal microscopy images of Sox2/BrdU/GFAP (d) and DCX/BrdU co-expression (e, arrows) in the adult DG of Mas mice; scale bar 100 µm