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Decreased baseline Trp and 5-HT levels in ACE2-deficient mice (ACE2). a–e Levels of Trp (a, c), 5-HT (b, d), and 5-HIAA, the degradation product of 5-HT (e), were significantly decreased in the blood (a, b) and brain (c–e) of ACE2 compared with WT. Unpaired Student’s t test, **p < 0.01, ***p < 0.001 indicate statistical significance relatively to WT; data are presented as mean ± SEM
