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a Schematic of dsRNA-dependent effector functions of PKR. b Structure of ribonuclease III dsRBD in complex with dsRNA (PDB: 2EZ6) [34]. No structure is currently available for PKR dsRBD in complex with dsRNA. Protein residues interacting with dsRNA are colored blue for basic residues and red for acidic residues. The minor and major grooves are indicated by m and M, respectively. c Summary of PKR-stimulatory and suppressive features of RNA
