Fig. 11.

LCN-2 is responsible for neutrophil sequestration into the eye. a Orthogonal projections from all three dimensions of a whole eye from a mouse injected with WT neutrophils + IFNλ. Cells within the retina and Schlemm’s canal were extracted as spot counts in Imaris software. Cells are depicted as green spheres b with and c without the orthogonal projection. d Counts extracted from all groups demonstrated an increase in neutrophil number (cell count) in the NOD-SCID mice injected (intravenous) with IFNλ-treated WT neutrophils compared to untreated controls, whereas loss of LCN-2 in neutrophils (LCN-2^−/−) showed reduced infiltration even after IFNλ exposure. n = 1. Scale bar, 500 μm.

Reproduced with permission from Ghosh et al. [96]