Fig. 13.

Activation of LCN-2 through the AKT2/NF-κB axis. a Immunoblot and summary of densitometry showing increased expression of both NF-κB-p65 subunit and LCN-2 in the retinas from 1 year old Cryba1 cKO mice. After intravitreal injections of Triciribine in Cryba1 cKO mice, the activation of both NF-κB and LCN-2 was significantly reduced. b Immunoblot data showing significant increase in expression of pAKT2 (S474) and NF-κB-p65 subunit in retinas of early AMD subjects compared to age-matched controls, which increased with disease severity (n = 3 donors/stage). Error bars indicate s.d.; *P < 0.05. **P < 0.01 relative to Cryba1^fl/fl. Adapted with permission from Ghosh et al. [92]