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AKT2-NF-κB-LCN-2 signaling in AMD. In AMD, AKT2-dependent NF-κB and STAT1 nuclear translocation drives lcn2 gene expression in the retinal pigment epithelium (RPE) cells (right panel), which is not observed in the control RPE cells (left panel). These upstream regulators of LCN-2 could be used as potential targets for lowering LCN-2 mRNA expression in AMD
