Table 2.

SAR displaying different substituents at 3, 4, and 5-positions of isoxazole moiety for various biological activities

Activity	Groups at 3-position	Groups at 4-position	Groups at 5-position
Analgesic	Methyl, carboxy	Unsubstituted	Substituted phenyl
Anti-inflammatory	Substituted phenyl	Substituted phenyl, pyridine	Indole, isopropyl
Anticancer	Substituted phenyl, furan, indole	Unsubstituted, arylsulfonyl, arylamido	Amino, arylamido, substituted phenyl, indole, thiazole, quinoline
Antimicrobial	Substituted phenyl, thiophene, benzofuran, amino	Arylsulfonyl, thiocyanate, 2-amino oxadiazole	Amino, halogen substituted phenyl, thienyl, thiazole
Antidepressant	Pyridine, pyrrole	Unsubstituted, piperazine	Indole, pyridine, substituted amine
Anticonvulsant	Hydroxyl, pyrrolidine	Substituted phenyl	piperidyl
Anti-Alzheimer	Substituted phenyl, pyridine	Unsubstituted, pyrazole	Substituted phenyl, Long chain alkyl, cyclohexene, pyrrolidine
Immunosuppressant	Substituted aryl	Unsubstituted, trifluoromethyl, amino	tert-butyl, oxadiazole