Table 2.
SAR displaying different substituents at 3, 4, and 5-positions of isoxazole moiety for various biological activities
| |||
|---|---|---|---|
| Activity | Groups at 3-position | Groups at 4-position | Groups at 5-position |
| Analgesic | Methyl, carboxy | Unsubstituted | Substituted phenyl |
| Anti-inflammatory | Substituted phenyl | Substituted phenyl, pyridine | Indole, isopropyl |
| Anticancer | Substituted phenyl, furan, indole | Unsubstituted, arylsulfonyl, arylamido | Amino, arylamido, substituted phenyl, indole, thiazole, quinoline |
| Antimicrobial | Substituted phenyl, thiophene, benzofuran, amino | Arylsulfonyl, thiocyanate, 2-amino oxadiazole | Amino, halogen substituted phenyl, thienyl, thiazole |
| Antidepressant | Pyridine, pyrrole | Unsubstituted, piperazine | Indole, pyridine, substituted amine |
| Anticonvulsant | Hydroxyl, pyrrolidine | Substituted phenyl | piperidyl |
| Anti-Alzheimer | Substituted phenyl, pyridine | Unsubstituted, pyrazole | Substituted phenyl, Long chain alkyl, cyclohexene, pyrrolidine |
| Immunosuppressant | Substituted aryl | Unsubstituted, trifluoromethyl, amino | tert-butyl, oxadiazole |