Fig. 2.

HPV16 E6-specific serum IgG and mucosal IgA production in mice following oral immunization with L. casei-PgsA-E6. a E6-specific serum IgG collected from mice orally immunized with L. casei-PgsA or L. casei-PgsA-E6 was determined by ELISA using recombinant His-E6 as a coating antigen. b E6-specific intestinal IgA and c vaginal IgA were determined in lavage fluids. Asterisks represent statistically significant differences relative to the L. casei-PgsA control (*p < 0.05; **p < 0.01). Data are given as mean ± SD of duplicate experiments