Fig. 6.

Therapeutic effect of orally administered L. casei-PgsA-E6 on TC-1 tumor. TC-1 tumor cells (2 × 10⁴ cells) were injected subcutaneously into C57BL/6 mice (ten per group) 3 days before the oral immunization of the L. casei-PgsA or the L. casei-PgsA-E6. a The percent rate of tumor-free mice, and b tumor size, and c survival rate of TC-1 tumor-bearing mice were checked. Tumor size was periodically monitored by measurement of two perpendicular diameters of the tumor and expressed as the tumor area (mm²). Asterisks represent statistically significant differences relative to the L. casei-PgsA control (*p < 0.05; **p < 0.01)