Fig. 8.

The depletion of CD4⁺ or CD8⁺ T cells eliminates the therapeutic antitumor effect of L. casei-PgsA-E6. In vivo depletion of CD4⁺ or CD8⁺ T cells (3 days before tumor challenge) was performed as mentioned in “Materials and methods”. a The percent rate of tumor-free mice, and b tumor size, and c survival rate of TC-1 tumor-bearing mice were examined. Tumor size was periodically monitored by measurement of two perpendicular diameters of the tumor and expressed as the tumor area (mm²). Asterisk represent statistically significant differences relative to the L. casei-PgsA control (*p < 0.05)