Table 1.

Sample information used in this study

Speciesa	Accession number
	TLR3	TLR7	TLR8	TLR9
Didelphimorphia
Monodelphis domestica	XM_007496035.1	XM_007500926.1	XM_007500927.1	XM_007500513.1
Dasyuromorphia
Sarcophilus harrisii	XM_012552074.1	XM_003765580.1	XM_003765579.2	XM_003762588.1
Dermoptera
Galeopterus variegatus	XM_008563573.1	XM_008571332.1	XM_008571342.1	NA
Lagomorpha
Oryctolagus cuniculus	NM_001082219.1	NA	NA	HM448400.1
Primates
Cercocebus torquatus atys	EU204935.1	EU204942.1	EU204945.1	EU204946.1
Gorilla gorilla	NM_001279752.1	KF321040.1	AB445669.1	AB445676.1
Homo sapiens	NM_003265.2	AK313858.1	BC101075.2	NM_017442.3
Macaca mulatta	NM_001036685.1	AB445665.1	AB445672.1	AB445679.1
Pan troglodytes	NM_001130470.1	NM_001130133.1	NM_001130472.1	NM_001144866.1
Pongo pygmaeus	AB445635.1	AB445663.1	AB445670.1	AB445677.1
Rodentia
Chinchilla lanigera	XM_005373438.2	XM_005411374.2	XM_005411373.2	XM_005410346.2
Cavia porcellus	NM_001173029.1	XM_003462893.3	XM_003462892.2	NA
Mus musculus	NM_126166.4	NM_001290755.1	AY035890.1	NM_031178.2
Octodon degus	XM_004639797.1	XM_004635044.1	XM_004635045.1	XM_012517625.1
Rattus norvegicus	NM_198791.1	NM_001097582.1	NM_001101009.1	NM_198131.1
Carnivora
Canis lupus familiaris	XM_540020.4	NM_001048124.2	XM_003435448.3	NM_001002998.1
Felis catus	NM_001079829.1	NM_001080133.1	EF484949.1	NM_001009285.1
Leptonychotes weddellii	XM_006741822.1	XM_006733443.1	NA	NA
Panthera tigris altaica	XM_007098990.1	XM_007090078.1	NA	XM_007081936.1
Ursus maritimus	XM_008710465.1	XM_008696372.1	XM_008696373.1	NA
Cetartiodactyla
Bos taurus	NM_001008664.1	NM_001033761.1	EF583902.1	NM_183081.1
Lipotes vexillifer	XM_007466549.1	XM_007455054.1	XM_007455053.1	NA
Ovis aries	NM_001135928.1	AM981305.1	NM_001135929.1	NM_001011555.1
Sus scrofa	NM_001097444.1	NM_001097434.1	NM_214187.1	NM_213958.1
Tursiops truncatus	XM_004321214.1	XM_004317713.1	XM_004317714.1	XM_004313247.1
Balaenoptera acutorostrata scammoni	XM_007173978.1	XM_007180334.1	XM_007180333.1	NA
Vicugna pacos	XM_006198002.1	XM_006212620.1	XM_006212621.1	XM_006220180.1
Physeter catodon	XM_007126456.1	XM_007121207.1	XM_007121208.1	NA
Eulipotyphla
Condylura cristata	XM_004682500.2	XM_004689851.2	XM_004689852.2	NA
Erinaceus europaeus	XM_007517692.1	XM_007517472.1	XM_007517473.1	XM_007519193.1
Sorex araneus	XM_004610405.1	XM_004612185.1	XM_004612186.1	XM_012934195.1
Perissodactyla
Ceratotherium simum simum	XM_004428766.1	XM_004435114.1	XM_004435115.1	NA
Equus caballus	NM_001081798.1	XM_005613953.1	NM_001111301.1	NM_001081790.2
Chiroptera
Carollia perspicillata	NA	NA	KU163598.1	NA
Desmodus rotundus	KR349157	KR349160	KR349163	KR349164
Eidolon helvum	NA	NA	KU163606.1	NA
Eptesicus fuscus	XM_008151907.1	XM_008156577.1	XM_008156576.1	NA
Miniopterus natalensis	XM_016211320.1	XM_016215635.1	XM_016202926.1	XM_016202449.1
Myotis brandtii	XM_005863096.1	XM_005880946.1	XM_005880947.1	XM_014529721.1
Myotis davidii	XM_006772707.1	XM_006763796.1	XM_006763795.1	XM_006770629.1
Myotis lucifugus	XM_006092654.1	XM_006088607.1	XM_006088606.1	XM_014448429.1
Myotis myotis	NA	NA	KU163595.1	NA
Noctilio leporinus	NA	NA	KU163601.1	NA
Noctilio albiventris	NA	NA	KU163600.1	NA
Nyctalus leisleri	NA	NA	KU163592.1	NA
Nyctalus noctula	NA	NA	KU163591.1	NA
Pteropus alecto	NM_001290169.1	NM_001290164.1	NM_001290163.1	GU045608.1
Pteropus vampyrus	XM_011363986.1	XM_011362910.1	XM_011362911.1	XM_011364642.1
Pteronotus parnellii	NA	NA	KU163599.1	NA
Pipistrellus nathusii	NA	NA	KU163593.1	NA
Rhinolophus hipposideros	NA	NA	KU163605.1	NA
Rhinolophus ferrumequinum	NA	NA	KU163604.1	NA
Rhinolophus euryale	NA	NA	KU163603.1	NA
Rousettus leschenaultii	AB472355.1	AB472356.1	NA	AB472357.1
Rousettus aegyptiacus	XM_016143919.1	XM_016119579.1	XM_016119482.1	XM_016133206.1
Saccopteryx bilineata	NA	NA	KU163602.1	NA
Vampyressa pusilla	NA	NA	KU163597.1	NA
Vampyressa bidens	NA	NA	KU163596.1	NA
Vespertilio murinus	NA	NA	KU163594.1	NA
Myotis ricketti	KU302512	KU577291	KU577298	KU577307
Rhinolophus affinis	KU302513	KU577292	KU577299	KU577308
Rhinolophus sinicus	KU302514	KU577293	KU577300	KU577309
Eonycteris spelaea	KU302515	KU577294	KU577301	NA
Ia io	KU302516	KU577295	KU577302	KU577310
Hipposideros armiger	KU302517	KU577296	KU577303	KU577311
Miniopterus schreibersii	KU302518	KU577297	NA	KU577312
Cynopterus sphinx	NA	NA	KU577304	NA
Pipistrellus abramus	NA	NA	KU577305	NA
Myotis altarium	NA	NA	KU577306	NA

NA species that lack a complete coding sequence for TLR in the NCBI database or were not identified in this study

^aSpecies in bold were sequenced in this study