Fig. 1.

Effects of 5-substituted 2-amino-4,6-dihydroxypyrimidines A1–A12 and 2-amino-4,6-dichloropyrimidines B1–B12 on the production of NO by mouse peritoneal cells (a) and their viability (b). The compounds were applied at a concentration of 50 µM. The NO data are means obtained from at least four experiments. The viability data were averaged from two to four experiments. All columns are mean ± SEM. Dotted lines denote 95 % confidential intervals of control values. * p < 0.05, ** p < 0.01, *** p < 0.001