Table 3.
Comparison of clinical variables between non-Hodgkin lymphoma patients with and without Pneumocystis pneumonia who received R-CHOP
| Variables | Definite only | Definite & probable | ||||
|---|---|---|---|---|---|---|
| PCP (%) N = 14 | Non-PCP (%) N = 699 | p value | PCP (%) N = 32 | Non-PCP (%) N = 681 | p value | |
| Male | 9 (64.3) | 396 (56.7) | 0.57 | 20 (62.5) | 385 (56.5) | 0.51 |
| Age (years), median (IQR) | 61 (42-65) | 58 (47-68) | 0.61 | 63 (53-71) | 57 (47-68) | 0.06 |
| Ann Arbor stage | ||||||
| I | 3 (21.4) | 146 (20.9) | 1.00 | 5 (15.6) | 144 (21.1) | 0.66 |
| II | 4 (28.6) | 183 (26.2) | 0.77 | 7 (21.9) | 180 (26.4) | 0.68 |
| III | 0 | 90 (12.9) | 0.24 | 4 (12.5) | 86 (12.6) | 1.00 |
| IV | 7 (50.0) | 280 (40.1) | 0.58 | 16 (50.0) | 271 (39.8) | 0.27 |
| Type of pathology | ||||||
| DLBL | 12 (85.7) | 660 (94.4) | 0.19 | 29 (90.6) | 643 (94.4) | 0.42 |
| MCL | 2 (14.3) | 25 (3.6) | 0.10 | 3 (9.4) | 24 (3.5) | 0.12 |
| Others | 0 (1.0) | 14 (2.0) | 1.00 | 0 | 14 (2.1) | 1.00 |
| Four or more cycles of R-CHOP | 12 (85.7) | 566 (81.0) | 0.74 | 22 (68.7) | 553 (81.3) | 0.11 |
| Laboratory data at the time of initial R-CHOP | ||||||
| ANC/mm3, median (IQR) | 3274 (2463–5873) | 3668 (2701–4964) | 0.98 | 3588 (2599–5803) | 3666 (2702–4920) | 0.80 |
| ALC/mm3, median (IQR) | 1467 (863–1690) | 1589 (1065–2151) | 0.27 | 1476 (1008–1765) | 1603 (1059–2152) | 0.39 |
| LDH IU/L, median (IQR) | 249 (188–415) | 243 (188–400) | 0.84 | 290 (199–422) | 241 (188–400) | 0.36 |
| Laboratory data at the time of last R-CHOP* | ||||||
| ANC/mm3, median (IQR) | 3664 (2111–5921) | 2615 (1858–3993) | 0.10 | 4742 (3039–6772) | 2627 (1866–4019) | <0.01 |
| ALC/mm3, median (IQR) | 864 (539–1377) | 1076 (786–1443) | 0.10 | 1003 (695–1590) | 1076 (783–1454) | 0.45 |
| LDH IU/L, median (IQR) | 351 (240–414) | 264 (217–320) | 0.06 | 309 (235–393) | 269 (217–326) | 0.07 |
| Decrease in ALC/mm3, median (IQR)† | 346 (-80–996) | 475 (-1–1008) | 0.25 | 346 (-349–1018) | 269 (217–327) | 0.39 |
| Prophylaxis for PCP | 0 | 13 (1.9) | 1.00 | 1 (3.1) | 12 (1.8) | 0.45 |
* Patients who received only one cycle of R-CHOP were excluded; † compared by analysis of covariance. Abbreviations: PCP: pneumocystis pneumonia; IQR: Interquartile range; DLBL: diffuse large B cell lymphoma; MCL: mantle cell lymphoma; ANC: absolute neutrophil count; ALC: absolute lymphocyte count; LDH: lactate dehydrogenase