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. Author manuscript; available in PMC: 2020 Mar 18.
Published in final edited form as: Biochem J. 2019 Jan 11;476(1):67–83. doi: 10.1042/BCJ20180792

Figure 3.

Figure 3.

Use of a CXCR4-targeting cyclotide as a bioimaging tool for detecting CXCR4-overexpressing tumor cells in animal models (24). Distribution of [64Cu]MCo-CVX-6D (CXCR4-targetign cyclotide) and [64Cu]MCoTI-ID (a DOTA-labeled variant of native trypsin inhibitor cyclotide MCoTI-I) in NOD/SCID mice bearing U87 and U87-stb-CXCR4 tumors with PET-CT. B. Ex vivo evaluation of [64Cu]MCo-CVX-6D and [64Cu]MCoTI-ID distribution and specificity in NOD/SCID mice bearing U87 and U87-stb-CXCR4 tumors. Ex vivo biodistribution analysis was performed at 90 min and 24 h after post tracers injection.