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Sequences and structures of naturally-occurring disulfide-rich backbone cyclized peptides θ-defensin (RTD-1) (A) and sunflower trypsin inhibitor 1 (SFTI-1) (B). The backbone cyclized peptide (connecting bond shown in blue) is stabilized by the three disulfide bonds in a ladder formation (disulfide bonds shown in yellow). Molecular graphics were created using Yasara (www.yasara.org).
