Table 1.
Baseline demographic, clinical, and molecular characteristics of patients treated with weekly ONC201 in nonsurgical and surgical arms
| Nonsurgical Arm (N = 20) | Surgical Arm (N = 6) | |
|---|---|---|
| Age, y, median (range) | 55 (20–74) | 65.5 (47–69) |
| Male:female | 10:10 | 1:5 |
| KPS, median (range) | 80 (20–80) | 85 (80–100) |
| Number of baseline lesions, median (range) | 1 (1–3) | 1 (1–2) |
| Number of recurrences | ||
| 1 | 16 (80%) | 5 (83%) |
| 2 | 3 (15%) | 1 (17%) |
| 3 | 1 (5%) | 0 (0%) |
| Prior low-grade diagnosis | 1 (5%) | 0 (0%) |
| Prior radiotherapy | 20 (100%) | 5 (83%) |
| Prior temozolomide | 20 (100%) | 6 (100%) |
| Extent of resection at the latest surgery | ||
| Subtotal (partial) | 3 (15%) | 0 (0%) |
| Gross total | 13 (65%) | 6 (100%) |
| Unknown | 4 (20%) | 1 (17%) |
| Salvage surgery at time of recurrence | 6 (30%) | 1 (17%) |
| MGMT | ||
| Methylated | 5 (25%) | 2 (33%) |
| Unmethylated | 11 (55%) | 4 (67%) |
| Unknown | 4 (20%) | 0 (0%) |
| H3 K27M | 3 (15%) | 0 (0%) |
| Corticosteroids at study entry | 18 (90%) | 5 (83%) |