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. 2020 Mar 18;15(3):e0230499. doi: 10.1371/journal.pone.0230499

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© 2020 Nowling et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 2 — Splenomegaly in the same mice as in Fig 1 was determined by absolute spleen weight (A) and as spleen to body weight ratio (B). (C) Percentages of activated/memory T cells (CD3⁺ CD44⁺ CD62L^-) were measured in spleen by flow cytometry. IgG levels were measured by ELISA in serum samples collected one day prior to treatment (Pre-treatment) and one day prior to euthanasia (Endpoint) with absolute levels (D) and change in levels from Pre-treatment to Endpoint (E) presented. Means with standard deviations are presented. Water, water-treated MRL/lpr mice; OP, OP-treated MRL/lpr mice; MpJ, MRL/MpJ (untreated) mice.