Fig. 1.

Illustration of different modes of tFUS configurations (human example). (A) Sonication of deep brain structures using a multi-element transducer. Red lines indicate the surface tangential to the skull with respect to the incident sonication beam originating from each element (in green line), (B) Sonication of cortical area near the skull surface. (C) Beam selection (in green line) by blocking (in yellow) or (D) use of single-element FUS transducer under the image-guidance to track the location of the transducer with respect to the head.