Table 4.

Differences between controls, pre-symptomatic and symptomatic patients for all speech and pause measures. Means for each group are presented with standard deviations in parentheses.

	Controls	ALS Pre-symptomatic	ALS Symptomatic	ANOVA p-value	2 SD cut-point
% Intelligibility, SIT	98.55 (1.22)	97.54 (3.33)	89.70 (20.58)	<0.0001	> 96.1
Speaking rate, SIT (WPM)	198.55 (21.80)	176.81 (33.26)	129.66 (38.91)	<0.0001	> 154.95
Speaking rate, Passage (WPM)	184.15 (23.50)	162.47 (28.78)	122.77 (35.11)	<0.0001	>137.15
Total duration (sec)	32.13 (4.16)	37.14 (7.78)	52.38 (18.28)	<0.0001	<40.45
Speech duration (sec)	26.95 (3.10)	30.22 (5.71)	40.81 (13.60)	<0.0001	<33.15
% Pause	15.81 (4.75)	18.09 (5.75)	21.75 (8.05)	<0.0001	<25.31
Pause events (count)	8.77 (2.14)	11.01 (4.09)	17.04 (9.86)	<0.0001	<13.05
Mean pause (sec)	0.58 (0.14)	0.62 (0.15)	0.70 (0.21)	<0.0001	<0.86
Mean phrase (sec)	2.89 (0.67)	2.75 (0.83)	2.55 (0.84)	<0.0001	< 4.23
CV phrase duration	0.46 (0.15)	0.52 (0.16)	0.53 (0.14)	<0.0001	<0.76
CV pause duration	0.33 (0.12)	0.36 (0.16)	0.41 (0.19)	<0.0001	<0.57

Bonferroni corrected p value=0.005

SD: Standard deviation; SIT: Speech Intelligibility Test; WPM: Words per minute; CV: Coefficient of variation