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Case study 2: Reference virtual subject for anti‐PCSK9 model optimized using scatter search. The results show model calibration to single dose clinical data at six dose levels (10, 40, 150, 300, 600, 800 mg) and three measurements: total anti‐PCSK9 (a, d, g), LDL (b, e, h), and total PCSK9 concentrations (c, f, i). Each plot contains data and reference virtual subject simulation for two dose levels as shown in the legends. PCSK9, proprotein convertase subtilisin/kexin type 9.
