Table 1.

Parameter values estimated from clinical data

Parameter	Patients' group	Mean	SE_mean	SD	2.50%	25%	50%	75%	97.50%	n_eff	$\widehat{R}$
$\text{TV}\_Y_0\left({\text{mm}}^3\right)$	Gefi+	292.70	0.81	50.88	204.97	258.50	289.12	321.75	407.27	3940.3	1.00
	Ch+	292.70	0.81	50.88	204.97	258.50	289.12	321.75	407.27	3940.3	1.00
	Gefi−	133.94	0.28	17.75	101.69	121.58	132.86	145.12	171.19	4000.0	1.00
	Ch−	133.94	0.28	17.75	101.69	121.58	132.86	145.12	171.19	4000.0	1.00
$\text{TV}\_k_{\text{gr}}\left(\frac{1}{\text{week}}\right)$	Gefi+	0.0092	0.0000	0.0020	0.0060	0.0078	0.0090	0.0104	0.0136	2650.3	1.00
	Ch+	0.0101	0.0000	0.0022	0.0065	0.0085	0.0098	0.0114	0.0152	2558.4	1.00
	Gefi−	0.0227	0.0002	0.0081	0.0101	0.0166	0.0217	0.0274	0.0421	1322.2	1.00
	Ch−	0.0176	0.0001	0.0058	0.0088	0.0135	0.0167	0.0209	0.0309	2064.1	1.00
$\text{TV}\_\mathrm{\alpha }\left(\frac{1}{\text{week}}\right)$	Gefi+	0.1356	0.0003	0.0183	0.1036	0.1229	0.1341	0.1472	0.1757	3013.7	1.00
	Ch+	0.1956	0.0007	0.0340	0.1393	0.1714	0.1922	0.2160	0.2709	2531.3	1.00
	Gefi−	0.1810	0.0126	0.2728	0.0076	0.0503	0.1031	0.2000	0.8550	467.0	1.01
	Ch−	0.1838	0.0015	0.0628	0.0938	0.1396	0.1733	0.2174	0.3351	1759.9	1.00
$\text{TV}\_{\mathrm{\Delta }}_{\mathrm{\lambda }}\left(\frac{1}{\text{week}}\right)$	Gefi+	0.3099	0.0006	0.0335	0.2495	0.2864	0.3088	0.3320	0.3817	3490.6	1.00
	Ch+	0.2325	0.0006	0.0303	0.1773	0.2117	0.2307	0.2516	0.2970	2843.8	1.00
	Gefi−	0.0410	0.0011	0.0248	0.0136	0.0260	0.0355	0.0485	0.1038	517.3	1.01
	Ch−	0.1758	0.0008	0.0391	0.1132	0.1481	0.1713	0.1986	0.2651	2327.0	1.00

Δ_λ, the maximum intensity of the drug effect; α, the rate of resistance emergence; Ch+, EGFR positive patients treated with chemotherapy; Ch−, EGFR negative patients treated with chemotherapy; Gefi+, EGFR‐positive patients treated with gefitinib; Gefi−, EGFR‐negative patients treated with gefitinib; k _gr, the net tumor growth rate; n_eff, effective sample size; SD, standard deviations; SE_mean, Monte Carlo standard errors; TV, Typical value; Y ₀, the initial tumor volume.