TABLE 1.
Top 20 upstream regulators identified by PP expression differences in NASH vs FL*
| Regulator | Expr Fold Change |
Molecule type | Activation z-score |
p-value of overlap |
Dataset genes downstream of regulators |
Regulators in network |
|---|---|---|---|---|---|---|
| TP53 | 2.511 | transcription regulator | 0.827 | 1.11E-31 | 89 | 19 |
| SP1 | 1.791 | transcription regulator | −0.149 | 2.77E-27 | 93 | 27 |
| BRCA1 | −7.69 | transcription regulator | 0.656 | 2.24E-19 | 94 | 22 |
| RELA | −2.677 | transcription regulator | −0.414 | 7.72E-19 | 84 | 17 |
| AKT1 | −2.385 | kinase | −0.519 | 3.23E-18 | 91 | 25 |
| IKBKB | 2.16 | kinase | 0.733 | 5.84E-18 | 67 | 15 |
| ERBB2 | 1.671 | kinase | −0.331 | 8.98E-18 | 99 | 24 |
| NFKB1 | −1.588 | transcription regulator | 0.945 | 4.92E-17 | 71 | 14 |
| FAS | 2.109 | transmembrane receptor | 1.267 | 1.25E-16 | 92 | 18 |
| BCL2 | −1.966 | transporter | −1.177 | 1.13E-15 | 95 | 21 |
| CD28 | −1.556 | transmembrane receptor | 2.072 | 9.84E-14 | 80 | 17 |
| NFKBIA | −1.735 | transcription regulator | −1.457 | 4.8E-13 | 83 | 16 |
| MTOR | 1.581 | kinase | 1 | 2.57E-12 | 86 | 17 |
| JAK2 | 2.089 | kinase | 0.872 | 4.75E-12 | 75 | 18 |
| ATM | −3.924 | kinase | −0.445 | 5.02E-12 | 95 | 22 |
| RAF1 | −2.626 | kinase | 0.878 | 1.46E-11 | 87 | 24 |
| TP73 | 3.272 | transcription regulator | 1.367 | 3.03E-11 | 89 | 16 |
| GSK3B | 1.533 | kinase | −1.125 | 4.35E-11 | 87 | 23 |
| CBL | −1.798 | transcription regulator | 1.067 | 3.79E-10 | 66 | 13 |
| PRKCZ | 1.783 | kinase | −1.912 | 4.15E-10 | 95 | 19 |
*
Data are generated by IPA (see Supplementary Table S4)