Table 2.
PPM1D inhibitors
| Compound name | Structure | IC50 cell proliferation | IC50 phosphatase activity | Animal study | Animal model | Shortcomings | Reference |
|---|---|---|---|---|---|---|---|
| M321237 |  |
− | 0.5μM /MCF7 | + | Transgenic mice/Xenograft | selectivity | 93 |
| CCT007093 |  |
− | 8.4μM /MCF7 | + | Knockout mice | selectivity | 94 |
| SPI-001 |  |
26.9μM /MCF7 | 86.9 nM /MCF7 | − | − | Need more test | 91,96 |
| SL-176 |  |
7.4μM /MCF7 | 110 nM /MCF7 | − | − | Need more test | 96 |
| GSK2830371 |  |
− | 6.0 nM /MCF7 | + | Xenograft | Low stability in blood | 90,98 |
| C23 |  |
0.98μM /MCF7 | − | + | Xenograft | Water solubility and bioavailability | 18 |