. Author manuscript; available in PMC: 2021 Apr 1.

Published in final edited form as: J Viral Hepat. 2019 Dec 9;27(4):428–436. doi: 10.1111/jvh.13235

Table 2.

Comparative performance of non-invasive tests for the diagnosis of cirrhosis in Hepatitis D

Non- invasive tests	Cut-offs for cirrhosis	Patients with cirrhosis (n = 18)	Patients without cirrhosis (n = 57)	Se (%)	Sp (%)	PPV (%)	NPV (%)	LR+	LR-	Correctly classified
VCTE – Ideal Cut-off (kPa)	≥14.0	14	8	77.8%	86.0%	63.6%	92.5%	5.55	0.26	63 (84.0%)
VCTE – Ideal Cut-off (kPa)	<14.0	4	49	77.8%	86.0%	63.6%	92.5%	5.55	0.26	63 (84.0%)
VCTE (kPa)³⁰	≥12.5	14	10	77.8%	82.5%	58.3%	92.2%	4.45	0.27	61 (81.3%)
VCTE (kPa)³⁰	<12.5	4	47	77.8%	82.5%	58.3%	92.2%	4.45	0.27	61 (81.3%)
FIB-4⁴¹	>3.6	10	6	90.9%	84.2%	62.5%	97.0%	5.75	0.11	42 (56.0%)
	NC	7	19
	<1.6	1	32
APRI¹⁶	>2.0	11	7	84.6%	83.3%	61.1%	94.6%	5.1	0.19	46 (61.3%)
	NC	5	15
	<1.0	2	35
AAR³⁹	≥1	9	10	50.0%	82.5%	47.4%	83.9%	2.86	0.61	56 (74.7%)
AAR³⁹	<1	9	47	50.0%	82.5%	47.4%	83.9%	2.86	0.61	56 (74.7%)
RPR⁴⁰	≥0.16	10	2	55.6%	96.5%	83.3%	87.3%	15.89	0.46	65 (86.7%)
RPR⁴⁰	<0.16	8	55	55.6%	96.5%	83.3%	87.3%	15.89	0.46	65 (86.7%)

Values expressed as n or n (%);

Abbreviations: Se, sensitivity; Sp, specificity; PPV, positive predictive value; NPV, negative predictive value; LR, likelihood ratio; NC, not categorized