Table 2.

Pharmacokinetic Model Parameters	Typical value	±	SEE		ω2	±	SEE	Shrinkage
THC
VC (L)	28.3	±	3.61		0.09	±	0.04	0.03
V2 (L)	45.5	±	5.37		−
V3 (L)	3327	±	736		−
Cl2 (L/min)	1.35	±	0.27		0.11	±	0.06	0.11
Cl3 (L/min)	1.30	±	0.30		0.21	±	0.09	0.21
Cle (L/min)	0.72	±	0.10		−
f	0.89	±	0.13		0.11	±	0.04	0.14
δLowDose	0.23	±	0.03
δHighDose	0.29	±	0.01
11‐OH‐THC
Clthc‐ > oh (L/min)	0.36	±	0.02		0.05	±	0.001	0.01
High dose split (f)	0.88	±	0.03		0.02	±	0.002	0.19
VC (L)	29.1	±	0.16		0.14	±	0.01	0.07
V2 (L)	113.8	±	0.66		3.02	±	0.12	0.09
V3 (L)	272.3	±	3.50		−
Cl2 (L/min)	4.77	±	0.05		−
Cl3 (L/min)	1.90	±	0.02		−
Cloh‐ > cooh (L/min)	0.78	±	0.05		−
δLowDose	0.24
δHighDose	0.19
δA‐LowDose (ng/mL)	1.91
δA‐HighDose (ng/mL)	0.41
THCCOOH
Cle (L/min)	0.12		0.02		0.12	±	0.001	0.01
δLowDose	0.18
δHighDose	0.24
δA‐LowDose (ng/mL)	0.68
δA‐HighDose (ng/mL)	0.51

THC = Δ9‐tetrahydrocannabinol; Cl_e = elimination clearance; Clthc‐ > oh = metabolic clearance from THC to 11‐OH‐THC; Cloh‐ > cooh = metabolic clearance from 11‐OH‐THC to THCCOOH; Q = intercompartmental clearance between the central compartment, Vc, and the peripheral compartments, V2 and V3; f = factor or ratio between the inhalation bioavailability of the high THC dose and the low dose; High dose split (f) = fraction of the low dose Clthc‐ > oh that is estimated for the high dose (the remaining clearance is assigned to Clthc‐ > thccooh; δA = additive intrasubject variability; δ = proportional (relative) intrasubject variability; ω² = intersubject variability; SEE = standard error of the estimate.