Figure 1. Potential molecular mechanisms for the pathological changes observed in cavin-1 deficiency.

Cavin-1 plays a critical role in caveolae formation. It also has functions in other cellular locations, such as nucleus and cytosol (left panel). Current studies have suggested it is involved in many important cellular processes (right panel). Further research is needed to elucidate which one(s) are responsible for the lipodystrophy and muscular dystrophy phenotypes.