Table 4.
Univariable and multivariable analysis of variables associated with CMR measured LVMI
| Variable | LVMI | ||||
|---|---|---|---|---|---|
| Univariable analysis (number of observations = 74, unless otherwise stated) |
Multivariable analysis R2 = 0.601, n = 68 |
||||
| Correlation coefficient | B (95% CI) | p value | B (95% CI) | p value | |
| Age* | 0.139 | 0.157 (− 0.106, 0.420) | 0.238 | 0.006 (− 0.215, 0.228) | 0.955 |
| Male sex* | 0.665 | 15.657 (11.50, 19.783) | < 0.001 | 14.764 (− 10.00, 19.528) | < 0.001 |
| Systolic blood pressure* | 0.344 | 0.184 (0.066, 0.302) | 0.003 | 0.122 (0.027, 0.217) | 0.013 |
| Ever smoked* | 0.186 | 3.905 (− 0.948, 8.758) | 0.113 | 3.759 (0.232, 7.285) | 0.037 |
| Body mass index | 0.005 | 0.017 (− 0.738, 0.773) | 0.964 | – | – |
| Waist/hip circumference | 0.327 | 43.661 (13.571, 73.750) (n = 72) | 0.005 | 3.899 (− 22.997, 30.795) | 0.773 |
| TC/HDL-C* | 0.059 | 0.608 (− 1.874, 3.091) (n = 71) | 0.626 | 0.278 (− 1.462, 2.018) | 0.750 |
| HOMA-IR | 0.137 | 0.642 (− 0.489, 1.773) (n = 69)† | 0.261 | – | – |
| NT-proBNP | 0.062 | 0.009 (− 0.27, 0.045) (n = 69) | 0.615 | – | – |
| RA disease duration* | 0.172 | 0.175 (− 0.060, 0.411) | 0.142 | 0.046 (− 0.133, 0.224) | 0.612 |
| 3 Variable DAS28 | 0.042 | 0.341 (− 1.585, 2.268) | 0.725 | – | – |
| ACPA* | − 0.156 | − 4.2121 (10.294, 2.053) (n = 73) | 0.187 | 2.014 (− 2.559, 6.587) | 0.382 |
| HAQ-DI | − 0.140 | − 1.883 (− 5.097, 1.331) (n = 70) | 0.247 | – | – |
| History of joint surgery | 0.112 | 2.587 (− 2.825, 7.998) | 0.344 | – | – |
| Current use of biological DMARD | − 0.008 | − 0.169 (− 5.413, 5.075) | 0.949 | – | – |
Bold values represent statistical significance
ACPA anti-citrullinated peptide antibody, CRP C-reactive protein, DAS28CRP 28-joint disease activity score, DMARD disease-modifying anti-rheumatic drug, HAQ-DI health assessment questionnaire-disability index, HOMA-IR homeostasis model of assessment of insulin resistance, LVMI LV mass index, NT-proBNP N-terminal pro-brain natriuretic peptide, TC/HDL-C total cholesterol/high-density lipoprotein cholesterol ratio
*Entered into linear regression model as associated with LV mass in the literature
†Excluding high outlier: Correlation coefficient B − 0.025 (95% CI − 2.732, 2.195) p = 0.828