Table 1.
Parameter values inferred for progenitor cell behavior in different murine epithelial regions as derived from quantitative lineage tracing.
| Tissue | Experimental model | Reference | min tcc (days) | Division rate, λ (/week) | Symmetric division prob., r | % of progenitor cells, ρ | Stratification rate, Γ (/week) |
|---|---|---|---|---|---|---|---|
| Esophagus | Lrig1-eGFP-CreERT/R26-flConfetti | 0.5 | 2.9 (2.7; 3.0) | 0.10 (0.07; 0.15) | 65 (50; 96) | 5.4 (2.9; 69.6) | |
| Ah-CreERT/R26flEYFP | 5 | 0.5 | 2.9 (2.7; 3.0) | 0.06 (0.04; 0.10) | 56 (50; 89) | 3.7 (2.9; 23.5) | |
| Paw Epidermis | Axin2-CreERT2/R26-Rainbow | 11 | 1 | 2.0 (1.7; 2.3) | 0.14 (0.12; 0.17) | 53 (49; 58) | 2.3 (1.9; 2.8) |
| Ear Epidermis | Ah-CreERT/R26flEYFP | 32 | 1 | 1.5 (1.2; 1.7) | 0.04 (0.03; 0.06) | 54 (47; 72) | 1.8 (1.3; 3.9) |
| Back Epidermis | Ah-CreERT/R26flEYFP | 22 | 2 | 1.2 (1.1; 1.3) | 0.04 (0.03; 0.07) | 61 (55; 76) | 1.9 (1.5; 3.8) |
Parameter values indicated correspond with the maximum likelihood estimate (MLE), values in parentheses are 95% confidence bounds (see Supplementary Methods for details).