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. 2020 Mar 18;3:130. doi: 10.1038/s42003-020-0842-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Gene expression variations between control and cKO cells were retrospectively analyzed and presented in a principal component analysis plots for each cluster. b Gene set enrichment analysis indicates enrichment of differential expresses genes in CD98 cKO cells over control cells in indicated signatures per cluster. c Heatmap of genes associated with apoptosis were displayed. d Expression of Bcl2l11, Casp3, Osm, Fos, Tnf, and Fas by CD98 cKO cells and control cells per individual cluster. The experiment was done once (scRNA-seq) with four biological replicates in each group.