Table 3.
Mean DNA methylation (%) observed for different CpGs island (Isl) located in ITGB5 (A), SPSC3 (B), and FZD3 (C) genes for NAR, BD, and SZ subjects
| (A) ITGB5 | ||||||
|---|---|---|---|---|---|---|
| Island 1 | Island 2 | rs10934702:C > Ta | ||||
| Pheno | N | Mean | N | Mean | N | CpG1 |
| NAR | 3 | 2.9 | 30 | 82.6 | 48 | 42.1 |
| BD | 3 | 2.9 | 30 | 83.0 | 10 | 41.5 |
| SZ | 3 | 2.2 | 30 | 82.7 | 2 | 44.2 |
| min | 0.0 | 15.8 | 4.9 | |||
| max | 28.5 | 98.0 | 91.2 | |||
| (B) SPCS3 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Island 1 | Island 2 | Island 3 | rs7694145:G > Ab,c | |||||||
| Pheno | N | Mean | N | Mean | N | Mean | N GG | N AG | GG | AG |
| NAR | 3 | 3.1 | 10 | 96.0 | 10 | 17.3 | 17 | 109 | 30.8 | 23.3 |
| BD | 3 | 2.5 | 10 | 97.1 | 10 | 16.8 | 1 | 21 | 29.4 | 16.2 |
| SZ | 3 | 3.5 | 10 | 97.0 | 10 | 17.0 | 4 | 20 | 34.2 | 15.7 |
| min | 0.0 | 75.6 | 8.7 | 0.0 | ||||||
| max | 26.5 | 100.0 | 46.6 | 67.7 | ||||||
| (C) FZD3 | ||
|---|---|---|
| Pheno | N | Mean |
| NAR | 199 | 45.2 |
| BD | 85 | 45.8 |
| SZ | 58 | 42.1 |
| min | 2.6 | |
| max | 89.1 | |
aNC_000003.11:g.124653868 C > T
bNC_000004.11:g.177285894 A > G
cOnly heterozygotes AG and homozygotes GG subjects have been analyzed since AA homozygotes are without CpG site