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. 2020 Mar 18;10:4941. doi: 10.1038/s41598-020-61723-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Assessment of the effects of BSH inhibitors on circulating bile acid signatures (a) heatplot showing relative representation of individual bile acid moieties for individual animals following their respective treatments. (b) lithocholic acid and (c) glycohyocholic acid levels are significantly altered in plasma samples following either CAPE or riboflavin treatments, similar trends are evident with carnosic acid. Data is represented as mean ± SD. Coloured subjects represent responder (RS) animals with black subjects classified as non-responders (NRS).