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. 2020 Mar 18;11:1426. doi: 10.1038/s41467-020-15214-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Spirosomes were incubated with different cofactors as indicated in the panel. The condition apo corresponds to the spirosomes as they were purified from E. coli. For each condition, five representative 2D classes are displayed. b CryoEM map of the extended spirosomes (incubated with NAD⁺, Fe²⁺, and CoA) obtained by single-particle analysis. An AdhE dimer is colored with each AdhE protomer in blue and light blue, respectively. Adjacent ADH domains are colored in orange and pink. c CryoEM map of the compact spirosomes (incubated with NADH and Fe²⁺) obtained by single-particle analysis. The same color codes as in b are used. d CryoEM map of the extended spirosomes obtained by helical reconstruction. Representative 2D classes of the helical segments are displayed and the refined helical parameters are indicated. The same color codes as in b are used. e CryoEM map of the compact spirosomes obtained by helical reconstruction. Representative 2D classes of the helical segments are displayed and the refined helical parameters are indicated. The same color code as in b are used.