Table 2.
Heritability estimation for psoriatic disease (adjusted with prevalence 1%) using both the LDAK and the GCTA methods presented with and without imputation and including and excluding SNPs located within the MHC region.
| h2 method |
SNPs | Genotyped | Imputed | ||||
|---|---|---|---|---|---|---|---|
| PsA | PsC | PsV | PsA | PsC | PsV | ||
| LDAK | All SNPs | 0.41 (0.09)a | 0.58 (0.06) | 0.37 (0.03) | 0.43 (0.07) | 0.50 (0.05) | 0.32 (0.03) |
| Exclude MHC SNPs | 0.25 (0.09) | 0.33 (0.06) | 0.22 (0.03) | 0.28 (0.08) | 0.29 (0.05) | 0.19 (0.03) | |
| GCTA | All SNPs | 0.39 (0.09) | 0.42 (0.09) | 0.26 (0.03) | 0.27 (0.07) | 0.34 (0.05) | 0.20 (0.03) |
| Exclude MHC SNPs | 0.32 (0.09) | 0.34 (0.06) | 0.22 (0.03) | 0.20 (0.07) | 0.27 (0.05) | 0.16 (0.03) | |
aThe value in the brackets is the standard deviation of h2.