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. 2020 Mar 18;5:23. doi: 10.1038/s41541-020-0173-x

Fig. 5. Effects of Anti-Pfs230C1 IgG subclass and avidity induced with Alum, CoPoP/PHAD and ISA720 adjuvants.

Fig. 5

a Three-dimensional plot showing impact of IgG2-to-IgG1 ratios and anti-Pfs230 IgG ELISA units (EU) in the feeder on transmission-reducing activity (TRA). Each point represents an independent experiment using the purified serum IgGs from 10 immunized mice and assessing TRA in 20 mosquitos. The asterisk shows a point that has an EU greater than 32500 (the actual EU was 39613). All percent TRA values less than 60% are shown as 60% in (a). Only values with EU greater than 2500 are shown. The (b) IgG2-to-IgG1 ratio and (c) avidity are shown. Each point reperesents the purified IgG from n = 10 mice. For (b) and (c), the Kruskal–Wallis test followed by Dunn’s multiple comparisons test were used for statistical analysis. **p < 0.01; ***p < 0.0005.