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. 2020 Mar 18;11(3):195. doi: 10.1038/s41419-020-2387-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Core analysis was performed based on the selection criteria in the IPA database overlaid with the microarray data from the ALDOA common signature using a 1.5-fold change cut-off. b qRT-PCR results showing the mRNA expression of DUSP4 and TRAF4 with or without overexpression of an exogenous ALDOA-encoding gene in CL1-0 cells. c Representative images of the density and morphology of spheroids in the nonsilenced group and with DUSP4 and TRAF4 knockdown in CL1-0 ALDOA-overexpressing cells. d Quantitative analysis of the spheroid diameters for the nonsilenced group and for those with several downstream targets that were knocked down in CL1-0 ALDOA cells is shown in the panels. e Quantitative analysis of the spheroid numbers per 200 cells for the nonsilenced group and for those with several downstream targets that were knocked down in the CL1-0 ALDOA cells is shown in the panels. In b, GAPDH was used as an internal loading control. The significance of the differences in b and d was analyzed using Student’s t-test.