Table 2.
Top 5 Differentially Methylated Positions associated with PD (continuous trait summed EDS association).
| CpG | Chr | Position | Gene | Featurec | Delta βd | p-value | FDR | p-value BACON |
FDR BACON |
|---|---|---|---|---|---|---|---|---|---|
| cg13986138 | 15 | 22963760 | CYFIP1 | Body | −7.49E−4 | 7.61E−8 | 0.016 | 3.27E−08 | 0.014 |
| cg10316525 | 15 | 40572137 | ANKRD63a | IGR | −1.46E−3 | 9.81E−9 | 0.042 | 8.93E−08 | 0.019 |
| cg12337011 | 2 | 28002424 | MRPL33 | 3′UTR | −1.24E−3 | 2.21E−5 | 0.800 | 3.32E−06 | 0.288 |
| cg13145550 | 7 | 1350879 | UNCXb | IGR | −6.57E−3 | 2.64E−5 | 0.800 | 3.36E−06 | 0.288 |
| cg15457795 | 3 | 9747183 | CPNE9 | Body | −8.86E−4 | 1.78E−5 | 0.800 | 8.15E−06 | 0.318 |
aCpG is located approximately 15 kb downstream of ANKRD63. bCpG is located approximately 80 kb downstream of UNCX. cBased on manifest feature annotation Illumina (hg19). dNegative beta-values indicate lower DNA methylation (hypo-methylation) in cases compared to controls. FDR < 0.05 was considered significant.