Table 2.
No. of cases | Sustained taper absolute dose reduction from peak dose, MME | Sustained taper percent dose reduction from peak dose, % | Sustained taper dose, MME | |
---|---|---|---|---|
Median [IQR] | Median [IQR] | Median [IQR] | ||
Total | 894 | 60 [44–90] | 69 [58–91] | 24 [7–38] |
Type of taper achieved | ||||
Discontinuation | 200 | 75 [60–100] | 100 [100–100] | 0 [0–0] |
Low ≤ 30 MME | 410 | 47 [35–62] | 69 [58–81] | 23 [15–28] |
Reduced ≥ 50% | 284 | 75 [53–122] | 58 [53–66] | 50 [38.5–67.5] |
Peak dose prior to taper | ||||
31–< 50 MME | 21 | 25 [18–40] | 51 [40–100] | 21 [0–27] |
50–< 90 MME | 481 | 47 [37–59] | 70 [57–93] | 20 [5–28] |
90–< 120 MME | 165 | 72 [60–90] | 71 [61–100] | 27 [0–39] |
120–< 150 MME | 84 | 87 [75–114] | 65 [58–92] | 44 [10.5–56] |
150–< 200 MME | 66 | 122 [103–145] | 68 [59–83] | 54 [27–67] |
200+ MME | 77 | 192 [148–269] | 68 [58–77] | 90 [57–120] |
Year of cohort entry | ||||
2011 | 531 | 66 [49–100] | 68 [57–89] | 27 [8–45] |
2012 | 138 | 51 [39–80] | 66 [57–85] | 24.5 [11–31] |
2013 | 81 | 53 [42–77] | 73 [60–91] | 20 [7–30] |
2014 | 79 | 58 [43–75] | 77 [61–100] | 19 [0–28] |
2015 | 65 | 55 [40–70] | 74 [59–100] | 19 [0–29] |
Age group at cohort entry, years | ||||
18–40 | 87 | 61 [44–92] | 77 [62–88] | 20 [7–30] |
41–60 | 507 | 62 [45–91] | 68 [57–93] | 26 [6–41] |
61+ | 300 | 58 [43–89] | 68 [57–89] | 24 [9–34] |
Sex | ||||
Female | 555 | 60 [44–90] | 68 [58–89] | 25 [8–37] |
Male | 339 | 61 [45–90] | 71 [57–100] | 24 [0–40] |
Race | ||||
White | 725 | 60 [44–90] | 69 [58–91] | 24 [7–38] |
African-American | 39 | 53 [43–90] | 77 [56–100] | 21 [0–30] |
American Indian | 19 | 61 [39–93] | 69 [54–87] | 23 [18–30] |
Alaskan Native | ||||
Asian | 4 | 62.5 [45–87.5] | 63 [61–82] | 26.5 [11.5–41.5] |
Hawaiian or other | 3 | 50 [34–74] | 56 [52–62] | 40 [32–46] |
Pacific Islander | ||||
Other | 16 | 55 [40–88.5] | 61 [53–70] | 30 [24.5–43] |
Mixed (more than 1) | 26 | 61 [45–68] | 67 [55–84] | 26 [9–41] |
Hispanic origin | ||||
No | 798 | 60 [44–90] | 69 [57–90] | 25 [8–37] |
Yes | 33 | 72 [45–89] | 67 [59–100] | 25 [0–40] |