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. 2020 Mar 12;10:333. doi: 10.3389/fonc.2020.00333

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Copyright © 2020 Li, Geng, Wu, Yang, Sun, Zhu, Xu and Sun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison of gene expression profiles with immune scores and stromal scores in breast cancer. (A) The significantly upregulated and downregulated genes in the high immune score group compared with the low score group are shown in the volcano plot (fold change > 2.0, p < 0.05). (B) The significantly upregulated and downregulated genes in the high stromal score group compared with the low score group are shown in the volcano plots (fold change > 2.0, p < 0.05). (C) Venn diagrams showing the commonly upregulated genes in both the high immune score group and high stromal score group. (D) Immune score DEGs in breast cancer displayed in a heat map. (E) Stromal score DEGs in breast cancer displayed in a heat map. (F–H) GO analysis results showing that commonly upregulated DEGs were particularly enriched in BP (F), CC (G), and MF (H). (I) The significantly enriched pathways of the commonly upregulated DEGs determined by KEGG analysis. GO, gene ontology; BP, biological process; CC, cell component; MF, molecular function; KEGG, Kyoto Encyclopedia of Genes and Genomes.